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Sialor (Anetholtrithion)
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Pharmacology
In addition to its choleretic activity, anetholtrithion has a positive effect on drug-induced asialias which may be due to the drug's direct action on the secretory cells of the salivary glands.
Approximately 30% of an orally administered dose is absorbed from the gastrointestinal tract, with 80% being excreted in the urine and the remainder in the bile.
In man, the average amounts of anetholtrithion recovered as the free p-hydroxyphenyltrithione metabolite or its o-glucuronide are 1.5to 3% and 12%, respectively. The yellow coloration of the urine resulting from anetholtrithion ingestion is due to the presence of the two metabolites.
In addition to its choleretic activity, anetholtrithion has a positive effect on drug-induced asialias which may be due to the drug's direct action on the secretory cells of the salivary glands.
Approximately 30% of an orally administered dose is absorbed from the gastrointestinal tract, with 80% being excreted in the urine and the remainder in the bile.
In man, the average amounts of anetholtrithion recovered as the free p-hydroxyphenyltrithione metabolite or its o-glucuronide are 1.5to 3% and 12%, respectively. The yellow coloration of the urine resulting from anetholtrithion ingestion is due to the presence of the two metabolites.
Indications
In Addition To Its Choleretic Activity, Anetholtrithion Has A Positive Effect On Drug-induced Asialias Which May Be Due To The Drug's Direct Action On The Secretory Cells Of The Salivary Glands.
Approximately 30% Of An Orally Administered Dose Is Absorbed From The Gastrointestinal Tract, With 80% Being Excreted In The Urine And The Remainder In The Bile.
In Man, The Average Amounts Of Anetholtrithion Recovered As The Free P-hydroxyphenyltrithione Metabolite Or Its O-glucuronide Are 1.5to 3% And 12%, Respectively. The Yellow Coloration Of The Urine Resulting From Anetholtrithion Ingestion Is Due To The Presence Of The Two Metabolites.
In Addition To Its Choleretic Activity, Anetholtrithion Has A Positive Effect On Drug-induced Asialias Which May Be Due To The Drug's Direct Action On The Secretory Cells Of The Salivary Glands.
Approximately 30% Of An Orally Administered Dose Is Absorbed From The Gastrointestinal Tract, With 80% Being Excreted In The Urine And The Remainder In The Bile.
In Man, The Average Amounts Of Anetholtrithion Recovered As The Free P-hydroxyphenyltrithione Metabolite Or Its O-glucuronide Are 1.5to 3% And 12%, Respectively. The Yellow Coloration Of The Urine Resulting From Anetholtrithion Ingestion Is Due To The Presence Of The Two Metabolites.
Contraindications
Jaundice, cirrhosis, biliary tract or common bile duct obstruction.
Jaundice, cirrhosis, biliary tract or common bile duct obstruction.
Safety Information / Warning
Information not available
Information not available
Precautions
Rarely, soft stools may be produced. If this persists, reduce the dosage to 25mg in the morning and 25mg in the evening.
Pregnancy and Lactation: Anetholtrithion's safety for use in human pregnancy has not been established. Therefore, the drug should not be used in pregnancy or lactation unless its use is deemed essential to the welfare of the mother and/or fetus.
Rarely, soft stools may be produced. If this persists, reduce the dosage to 25mg in the morning and 25mg in the evening.
Pregnancy and Lactation: Anetholtrithion's safety for use in human pregnancy has not been established. Therefore, the drug should not be used in pregnancy or lactation unless its use is deemed essential to the welfare of the mother and/or fetus.
Side Effects / Adverse Effects
Information not available
Information not available
Recommended Dosage
25mg, 3times a day before meals. Treatment may be continuous or intermittent with 5drug free days per month in association with the drugs responsible for the asialia. In hyposialosis related to radiotherapy, administration may be continued indefinitely. Usually, anetholtrithion's full therapeutic effect is gradually achieved after several days of treatment.
25mg, 3times a day before meals. Treatment may be continuous or intermittent with 5drug free days per month in association with the drugs responsible for the asialia. In hyposialosis related to radiotherapy, administration may be continued indefinitely. Usually, anetholtrithion's full therapeutic effect is gradually achieved after several days of treatment.
Supplied / Packaging
Each orange-red, sugar-coated tablet contains: anetholtrithion 25mg. Nonmedicinal ingredients: anticaking sucrose, cochineal redA, Ewax, gelatin, gum arabic, guar gum, hydrated colloidal silica, lactose, magnesium stearate, sucrose, sunset yellowS, talc, titanium dioxide and wheat starch. Boxes of60.
Each orange-red, sugar-coated tablet contains: anetholtrithion 25mg. Nonmedicinal ingredients: anticaking sucrose, cochineal redA, Ewax, gelatin, gum arabic, guar gum, hydrated colloidal silica, lactose, magnesium stearate, sucrose, sunset yellowS, talc, titanium dioxide and wheat starch. Boxes of60.
